Research Guides: Internal Medicine Residency Readings: Morning Report 20-21

Education

Instructions:

Access NEJM Resident 360 via Himmelfarb Library to create a free personal account using your @gwu.edu email address.
After creating your account, you may access via the library or by direct access to NEJM Resident 360.

Access: NEJM Interactive Cases

Access: NEJM Videos in Clinical Medicine

Critical Care Primer

Critical Care Primer: Educational Resources for Non-ICU Clinicians
Link to free online training by the Society of Critical Care Medicine as well as additional information resources including: video tutorials, handbooks, and key review articles plus weekly clinical updates from the GW Division of Infectious Diseases.

COVID-19 Vaccines

Moderna Covid-19 Vaccine (mRNA-1273)

Moderna Covid-19 Vaccine - Efficacy and Safety
Vaccines and Related Biological Products Advisory Committee Briefing Document for December 17, 2020 Meeting.
Vaccines and Related Biological Products Advisory Committee
Planned December 17, 2020 discussion of Emergency Use Authorization (EUA) of the Moderna, Inc., COVID-19 Vaccine. Watch for additional materials.
Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination
Widge AT, Rouphael NG, Jackson LA, et al. Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination [published online ahead of print, 2020 Dec 3]. N Engl J Med. 2020;NEJMc2032195. doi:10.1056/NEJMc2032195
Moderna: An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Jackson LA, Anderson EJ, Rouphael NG, et al. An mRNA Vaccine against SARS-CoV-2 - Preliminary Report. N Engl J Med. 2020;383(20):1920-1931. doi:10.1056/NEJMoa2022483
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
Anderson EJ, Rouphael NG, Widge AT, et al. Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults. N Engl J Med. 2020;383(25):2427-2438. doi:10.1056/NEJMoa2028436
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
Corbett KS, Flynn B, Foulds KE, et al. Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates. N Engl J Med. 2020;383(16):1544-1555. doi:10.1056/NEJMoa2024671

Pfizer-BioNTech COVID-19 Vaccine (BNT162b2)

Pfizer-Biontech COVID-19 - Includes summary of clinical data
Vaccines and Related Biological Products Advisory Committee Briefing Document for December 10, 2020 Meeting.
Dec 10 FDA Meeting on Pfizer-BioNTech COVID-19 Vaccine: Handouts
Pfizer vaccine data (news report not full report)
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
Walsh EE, Frenck RW Jr, Falsey AR, Kitchin N, Absalon J, Gurtman A, Lockhart S, Neuzil K, Mulligan MJ, Bailey R, Swanson KA, Li P, Koury K, Kalina W, Cooper D, Fontes-Garfias C, Shi PY, Türeci Ö, Tompkins KR, Lyke KE, Raabe V, Dormitzer PR, Jansen KU, Şahin U, Gruber WC. Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates. N Engl J Med. 2020 Oct 14:NEJMoa2027906. doi: 10.1056/NEJMoa2027906. Epub ahead of print. PMID: 33053279; PMCID: PMC7583697.

Other COVID-19 Vaccine Data

Maintaining Safety with SARS-CoV-2 Vaccines
Castells MC, Phillips EJ. Maintaining Safety with SARS-CoV-2 Vaccines [published online ahead of print, 2020 Dec 30]. N Engl J Med. 2020;10.1056/NEJMra2035343. doi:10.1056/NEJMra2035343
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
Lancet DOI:https://doi.org/10.1016/S0140-6736(20)32661-1

February 18, 2021

Hypersensitivity pneumonitis (includes diagnostic images)
Costabel U, Miyazaki Y, Pardo A, Koschel D, Bonella F, Spagnolo P, Guzman J, Ryerson CJ, Selman M. Hypersensitivity pneumonitis. Nat Rev Dis Primers. 2020 Aug 6;6(1):65. doi: 10.1038/s41572-020-0191-z. PMID: 32764620.
Why factor XI deficiency is a clinical concern
Wheeler AP, Gailani D. Why factor XI deficiency is a clinical concern. Expert Rev Hematol. 2016 Jul;9(7):629-37. doi: 10.1080/17474086.2016.1191944. Epub 2016 Jun 24. PMID: 27216469; PMCID: PMC4950943.
Congenital factor XI deficiency: an update
Duga S, Salomon O. Congenital factor XI deficiency: an update. Semin Thromb Hemost. 2013 Sep;39(6):621-31. doi: 10.1055/s-0033-1353420. Epub 2013 Aug 8. PMID: 23929304.

February 11, 2021

Hemolytic Anemia
Phillips J, Henderson AC. Hemolytic Anemia: Evaluation and Differential Diagnosis. Am Fam Physician. 2018 Sep 15;98(6):354-361. PMID: 30215915.
Renal artery stenosis
Colbert GB, Abra G, Lerma EV. Update and review of renal artery stenosis. Dis Mon. 2020 Dec 7:101118. doi: 10.1016/j.disamonth.2020.101118. Epub ahead of print. PMID: 33303204.

February 4, 2020

Accidental hypothermia
Brown DJ, Brugger H, Boyd J, Paal P. Accidental hypothermia. N Engl J Med. 2012 Nov 15;367(20):1930-8. doi: 10.1056/NEJMra1114208. Erratum in: N Engl J Med. 2013 Jan 24;368(4):394. PMID: 23150960.

Hypothermia Hotlines

If you see someone out in the cold:

DC: 800-535-7252
Arlington: 703-228-7395

February 1, 2020

Journal Club: Controlled Trial of Budesonide-Formoterol as Needed for Mild Asthma
Beasley R, Holliday M, Reddel HK, BraithwaiBeasley R, Holliday M, Reddel HK, Braithwaite I, Ebmeier S, Hancox RJ, Harrison T, Houghton C, Oldfield K, Papi A, Pavord ID, Williams M, Weatherall M; Novel START Study Team. Controlled Trial of Budesonide-Formoterol as Needed for Mild Asthma. N Engl J Med. 2019 May 23;380(21):2020-2030. doi: 10.1056/NEJMoa1901963. Epub 2019 May 19. PMID: 31112386.. N Engl J Med. 2019 May 23;380(21):2020-2030. doi: 10.1056/NEJMoa1901963. Epub 2019 May 19. PMID: 31112386.
Asthma - clinical review
Tripple JW, Ameredes BT, Calhoun WJ. Outpatient Management of Chronic Asthma in 2020. JAMA. 2020 Feb 11;323(6):561-562. doi: 10.1001/jama.2019.19986. PMID: 32044930.
Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program
Cloutier MM, Dixon AE, Krishnan JA, Lemanske RF Jr, Pace W, Schatz M. Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program. JAMA. 2020 Dec 8;324(22):2301-2317. doi: 10.1001/jama.2020.21974. PMID: 33270095.

January 28, 2021

Late graft failure in heart transplant recipients
López-Sainz Á, Barge-Caballero E, Barge-Caballero G, Couto-Mallón D, Paniagua-Martin MJ, Seoane-Quiroga L, Iglesias-Gil C, Herrera-Noreña JM, Cuenca-Castillo JJ, Vázquez-Rodríguez JM, Crespo-Leiro MG. Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes. Eur J Heart Fail. 2018 Feb;20(2):385-394. doi: 10.1002/ejhf.886. Epub 2017 Jun 5. PMID: 28580728.
Irritable Bowel Syndrome
Sultan S, Malhotra A. Irritable Bowel Syndrome. Ann Intern Med. 2017 Jun 6;166(11):ITC81-ITC96. doi: 10.7326/AITC201706060. PMID: 28586906.
Colon Ischemia: An Update for Clinicians
Cotter TG, Bledsoe AC, Sweetser S. Colon Ischemia: An Update for Clinicians. Mayo Clin Proc. 2016 May;91(5):671-7. doi: 10.1016/j.mayocp.2016.02.006. PMID: 27150214.
Ischemic Colitis as a Complication of Medication Use (Alosetron)
Bielefeldt K. Ischemic Colitis as a Complication of Medication Use: An Analysis of the Federal Adverse Event Reporting System. Dig Dis Sci. 2016 Sep;61(9):2655-65. doi: 10.1007/s10620-016-4162-x. Epub 2016 Apr 12. PMID: 27073073.

January 15, 2020

Evaluation of the Solitary Pulmonary Nodule
Kikano GE, Fabien A, Schilz R. Evaluation of the Solitary Pulmonary Nodule. Am Fam Physician. 2015 Dec 15;92(12):1084-91. PMID: 26760594.
Patient-Centered, Guideline-Concordant Discussion and Management of Pulmonary Nodules
Wiener DC, Wiener RS. Patient-Centered, Guideline-Concordant Discussion and Management of Pulmonary Nodules. Chest. 2020 Jul;158(1):416-422. doi: 10.1016/j.chest.2020.02.007. Epub 2020 Feb 17. PMID: 32081651.
Solitary Pulmonary Nodule Malignancy Risk (Mayo Clinic model)
Based on: Swensen SJ, Silverstein MD, Ilstrup DM, et al. The probability of malignancy in solitary pulmonary nodules. Application to small radiologically indeterminate nodules. Arch Intern Med. 1997 Apr 28;157(8):849-55.
Lung‐RADS® Version 1.1 Assessment Categories Release date: 2019
Non-Small Cell Lung Cancer
Duma N, Santana-Davila R, Molina JR. Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment. Mayo Clin Proc. 2019;94(8):1623–1640. doi:10.1016/j.mayocp.2019.01.013
Small-cell lung cancer
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA. Current Diagnosis and Management of Small-Cell Lung Cancer. Mayo Clin Proc. 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. Review. PubMed PMID: 31378235.

January 14, 2021

Thrombotic thrombocytopenic purpura
Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K. Thrombotic thrombocytopenic purpura. Nat Rev Dis Primers. 2017 Apr 6;3:17020. doi: 10.1038/nrdp.2017.20. PMID: 28382967.

January 13, 2021

A Clinical Approach to Diagnosing Encephalopathy
Erkkinen MG, Berkowitz AL. A Clinical Approach to Diagnosing Encephalopathy. Am J Med. 2019 Oct;132(10):1142-1147. doi: 10.1016/j.amjmed.2019.07.001. Epub 2019 Jul 19. PMID: 31330129.
Diagnosis and management of acute encephalitis: A practical approach
Venkatesan A, Geocadin RG. Diagnosis and management of acute encephalitis: A practical approach. Neurol Clin Pract. 2014 Jun;4(3):206-215. doi: 10.1212/CPJ.0000000000000036. PMID: 25110619; PMCID: PMC4121461.
See Table 1: Diagnostic Criteria for Encephalitis
Autoimmune encephalitis
Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, Cortese I, Dale RC, Gelfand JM, Geschwind M, Glaser CA, Honnorat J, Höftberger R, Iizuka T, Irani SR, Lancaster E, Leypoldt F, Prüss H, Rae-Grant A, Reindl M, Rosenfeld MR, Rostásy K, Saiz A, Venkatesan A, Vincent A, Wandinger KP, Waters P, Dalmau J. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. 2016 Apr;15(4):391-404. doi: 10.1016/S1474-4422(15)00401-9. Epub 2016 Feb 20. PMID: 26906964; PMCID: PMC5066574.
Autoimmune encephalitis (includes typical presentations)
Goodfellow JA, Mackay GA. Autoimmune encephalitis. J R Coll Physicians Edinb. 2019 Dec;49(4):287-294. doi: 10.4997/JRCPE.2019.407. PMID: 31808454.
CNS Vasculitis: an Approach to Differential Diagnosis and Management
Byram K, Hajj-Ali RA, Calabrese L. CNS Vasculitis: an Approach to Differential Diagnosis and Management. Curr Rheumatol Rep. 2018 May 30;20(7):37. doi: 10.1007/s11926-018-0747-z. PMID: 29846828.
Creutzfeldt-Jakob disease: recent developments
Mackenzie G, Will R. Creutzfeldt-Jakob disease: recent developments. F1000Res. 2017 Nov 27;6:2053. doi: 10.12688/f1000research.12681.1. PMID: 29225787; PMCID: PMC5710312.
In the Clinic: Delirium
Mattison MLP. In the Clinic: Delirium. Ann Intern Med. 2020 Oct 6;173(7):ITC49-ITC64. doi: 10.7326/AITC202010060. PMID: 33017552.
Vascular disease in cocaine addiction
Bachi K, Mani V, Jeyachandran D, Fayad ZA, Goldstein RZ, Alia-Klein N. Vascular disease in cocaine addiction. Atherosclerosis. 2017 Jul;262:154-162. doi: 10.1016/j.atherosclerosis.2017.03.019. Epub 2017 Mar 14. PMID: 28363516; PMCID: PMC5757372.
Full Recovery From Cocaine-Induced Toxic Leukoencephalopathy
Mader EC Jr, Ramos AB, Cruz RA, Branch LA. Full Recovery From Cocaine-Induced Toxic Leukoencephalopathy: Emphasizing the Role of Neuroinflammation and Brain Edema. J Investig Med High Impact Case Rep. 2019 Jan-Dec;7:2324709619868266. doi: 10.1177/2324709619868266. PMID: 31409155; PMCID: PMC6696843.

January 8, 2020

Immune Reconstitution Inflammatory Syndrome (IRIS): What pathologists should know
Nelson AM, Manabe YC, Lucas SB. Immune Reconstitution Inflammatory Syndrome (IRIS): What pathologists should know. Semin Diagn Pathol. 2017 Jul;34(4):340-351. doi: 10.1053/j.semdp.2017.04.010. Epub 2017 Apr 26. PMID: 28552210.
Paradoxical Reactions and the Immune Reconstitution Inflammatory Syndrome
Church LWP, Chopra A, Judson MA. Paradoxical Reactions and the Immune Reconstitution Inflammatory Syndrome. Microbiol Spectr. 2017 Mar;5(2). doi: 10.1128/microbiolspec.TNMI7-0033-2016. PMID: 28303782.
HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment
Bowen LN, Smith B, Reich D, Quezado M, Nath A. HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment. Nat Rev Neurol. 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149. PMID: 27786246.
Cytomegalovirus Retinitis in HIV and Non-HIV Individuals
Munro M, Yadavalli T, Fonteh C, Arfeen S, Lobo-Chan AM. Cytomegalovirus Retinitis in HIV and Non-HIV Individuals. Microorganisms. 2019 Dec 28;8(1):55. doi: 10.3390/microorganisms8010055. PMID: 31905656; PMCID: PMC7022607.