Title: Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis
Publisher: The Lancet Gastroenterology and Hepatology
Publication Date: May 12, 2020
Key Takeaway: Meta-analysis of 35 studies (6686 patients) revealed pooled prevalence of digestive symptoms (often nausea/vomiting, diarrhea, or loss of appetite) was 15%, abnormal liver function was 19%. Subgroup analysis showed patients with severe COVID-19 had significantly higher rates of gastrointestinal symptoms and liver injury compared with those with non-severe disease (odds ratio [OR] 1.60 [95% CI 1.09–2.36]; p=0.0020; I²=44%), OR (2.20 [1.60–3.02]; p<0.00001; I²=36% respectively). Pediatric COVID patients had a similar prevalence of GI symptoms to those of adults.
Title: New COVID-19 guidance for gastroenterologists
Publisher: American Gastroenterological Association
Publication Date: 04 May 2020
Key Takeaway: GI symptoms might not be as common as originally thought in COVID. Abnormalities in liver function tests, however, should prompt thorough evaluation.