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July 16, 2021
Stimulant and Designer Drug Use: Primary Care Management
Clinical effects and treatment of persons who use cocaine, methamphetamines, 3,4-methylenedioxymethamphetamine (MDMA), synthetic cannabinoids, and synthetic cathinones (“bath salts”).
Klega AE, Keehbauch JT. Stimulant and Designer Drug Use: Primary Care Management. Am Fam Physician. 2018 Jul 15;98(2):85-92. PMID: 30215997.
Urine Drug Tests: Ordering and Interpreting Results.
Kale N. Urine Drug Tests: Ordering and Interpreting Results. Am Fam Physician. 2019 Jan 1;99(1):33-39. PMID: 30600984.
Clinical Interpretation of Urine Drug Tests: What Clinicians Need to Know About Urine Drug Screens.
Moeller KE, Kissack JC, Atayee RS, Lee KC. Clinical Interpretation of Urine Drug Tests: What Clinicians Need to Know About Urine Drug Screens. Mayo Clin Proc. 2017 May;92(5):774-796. doi: 10.1016/j.mayocp.2016.12.007. Epub 2017 Mar 18. PMID: 28325505.
Putting the MD back into MDMA
Nutt DJ, de Wit H. Putting the MD back into MDMA. Nat Med. 2021 Jun;27(6):950-951. doi: 10.1038/s41591-021-01385-8. PMID: 34031606.
Schwarz ES. Inhalants. Crit Care Clin. 2021 Jul;37(3):687-702. doi: 10.1016/j.ccc.2021.03.014. PMID: 34053714.
Journey JD, Bentley TP. Phencyclidine Toxicity. 2020 Nov 18. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 29939642.
Sex and Gender Differences in Substance Use
For most age groups, men have higher rates of use or dependence on illicit drugs and alcohol than do women.However, women are just as likely as men to develop a substance use disorder. In addition, women may be more susceptible to craving and relapse, which are key phases of the addiction cycle.
Research has shown that women often use drugs differently, respond to drugs differently, and can have unique obstacles to effective treatment as simple as not being able to find child care or being prescribed treatment that has not been adequately tested on women.
Treatment of opioid use disorder in primary care
Buresh M, Stern R, Rastegar D. Treatment of opioid use disorder in primary care. BMJ. 2021 May 19;373:n784. doi: 10.1136/bmj.n784. PMID: 34011512.
Hallucinogen Use Disorders
Hardaway R, Schweitzer J, Suzuki J. Hallucinogen Use Disorders. Child Adolesc Psychiatr Clin N Am. 2016 Jul;25(3):489-96. doi: 10.1016/j.chc.2016.03.006. Epub 2016 Apr 18. PMID: 27338969.
July 14, 2021
Diagnosis and Management of Dementia
Arvanitakis Z, Shah RC, Bennett DA. Diagnosis and Management of Dementia: Review. JAMA. 2019 Oct 22;322(16):1589-1599. doi: 10.1001/jama.2019.4782. PMID: 31638686; PMCID: PMC7462122.
In the Clinic: Dementia
Oh ES, Rabins PV. Dementia. Ann Intern Med. 2019 Sep 3;171(5):ITC33-ITC48. doi: 10.7326/AITC201909030. PMID: 31476229.
Brief Cognitive Testing in the Detection and Diagnosis of Clinical Alzheimer-Type Dementia
Saguil A, Buck E. Brief Cognitive Testing in the Detection and Diagnosis of Clinical Alzheimer-Type Dementia. Am Fam Physician. 2021 Feb 1;103(3):183-185. PMID: 33507046.
Update on HIV dementia and HIV-associated neurocognitive disorders
Brew BJ, Chan P. Update on HIV dementia and HIV-associated neurocognitive disorders. Curr Neurol Neurosci Rep. 2014 Aug;14(8):468. doi: 10.1007/s11910-014-0468-2. PMID: 24938216.
Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT, Nixon RA, Jones DT. Alzheimer disease. Nat Rev Dis Primers. 2021 May 13;7(1):33. doi: 10.1038/s41572-021-00269-y. PMID: 33986301.
Why is amyloid-β decreased in the CSF of Alzheimer Disease patients?
Lee JC, Kim SJ, Hong S, Kim Y. Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers. Exp Mol Med. 2019 May 9;51(5):1-10. doi: 10.1038/s12276-019-0250-2. PMID: 31073121; PMCID: PMC6509326.
Schizophrenia vs AD
Mohammadi A, Amooeian VG, Rashidi E. Dysfunction in Brain-Derived Neurotrophic Factor Signaling Pathway and Susceptibility to Schizophrenia, Parkinson's and Alzheimer's Diseases. Curr Gene Ther. 2018;18(1):45-63. doi: 10.2174/1566523218666180302163029. PMID: 29512462.
July 7, 2021
Reich DS, Lucchinetti CF, Calabresi PA. Multiple Sclerosis. N Engl J Med. 2018 Jan 11;378(2):169-180. doi: 10.1056/NEJMra1401483. PMID: 29320652; PMCID: PMC6942519.
Diagnosis and Treatment of Multiple Sclerosis: A Review
McGinley MP, Goldschmidt CH, Rae-Grant AD. Diagnosis and Treatment of Multiple Sclerosis: A Review. JAMA. 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. Erratum in: JAMA. 2021 Jun 1;325(21):2211. PMID: 33620411.
Typical MRI findings CIS
Miller DH, Chard DT, Ciccarelli O. Clinically isolated syndromes. Lancet Neurol. 2012 Feb;11(2):157-69. doi: 10.1016/S1474-4422(11)70274-5. PMID: 22265211.
NEJM Journal Watch
Summaries of recent studies + commentary on clinical significance.
Keeping up with new information
Learn how to use Browzine, NEJM Journal Watch, journal and database alerts, and podcasts to keep up with new medical information!
Keeping Up with Health Sciences Information
"Try to read something medical every day. This will help you to stay abreast of new developments and provide an opportunity to become reacquainted with things that you've learned and forgotten. Medicine is less about achieving mastery then it is about reinforcing old lessons. Our individual "knowledge tanks" leak information on a daily basis. There is no way to plug the hole. Instead, you must continually replenish by adding to the top."
Goldberg, C. (2018). A few thoughts before you go... Practical Guide to Clinical Medicine. https://meded.ucsd.edu/clinicalmed/thoughts.html