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NEJM Journal Watch
Summaries of recent studies + commentary on clinical significance.
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Keeping up with new information
Learn how to use Browzine, NEJM Journal Watch, journal and database alerts, and podcasts to keep up with new medical information!
Keeping Up with Health Sciences Information
"Try to read something medical every day. This will help you to stay abreast of new developments and provide an opportunity to become reacquainted with things that you've learned and forgotten. Medicine is less about achieving mastery then it is about reinforcing old lessons. Our individual "knowledge tanks" leak information on a daily basis. There is no way to plug the hole. Instead, you must continually replenish by adding to the top."
Goldberg, C. (2018). A few thoughts before you go... Practical Guide to Clinical Medicine. https://meded.ucsd.edu/clinicalmed/thoughts.html
July 7, 2021
- Multiple sclerosisReich DS, Lucchinetti CF, Calabresi PA. Multiple Sclerosis. N Engl J Med. 2018 Jan 11;378(2):169-180. doi: 10.1056/NEJMra1401483. PMID: 29320652; PMCID: PMC6942519.
- Diagnosis and Treatment of Multiple Sclerosis: A ReviewMcGinley MP, Goldschmidt CH, Rae-Grant AD. Diagnosis and Treatment of Multiple Sclerosis: A Review. JAMA. 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. Erratum in: JAMA. 2021 Jun 1;325(21):2211. PMID: 33620411.
- Typical MRI findings CISMiller DH, Chard DT, Ciccarelli O. Clinically isolated syndromes. Lancet Neurol. 2012 Feb;11(2):157-69. doi: 10.1016/S1474-4422(11)70274-5. PMID: 22265211.
June 11, 2021
- Hypertensive Heartbreak (interactive case)Lau ES, Vaidya A, Schaefer IM, Scirica BM. Hypertensive Heartbreak. N Engl J Med. 2021 May 27;384(21):e80. doi: 10.1056/NEJMimc2031595. PMID: 34042392.
- Hypertensive Heartbreak (article)Lau ES, Scirica B, Schaefer IM, Miller AL, Loscalzo J. Hypertensive Heartbreak. N Engl J Med. 2021 Jun 3;384(22):2145-2152. doi: 10.1056/NEJMcps2018493. PMID: 34077647.
- Takotsubo cardiomyopathyCusmà-Piccione M, Longobardo L, Oteri A, Manganaro R, Di Bella G, Carerj S, Khandheria BK, Zito C. Takotsubo cardiomyopathy: queries of the current era. J Cardiovasc Med (Hagerstown). 2018 Nov;19(11):624-632. doi: 10.2459/JCM.0000000000000707. PMID: 30234685.
- PheochromocytomaNeumann HPH, Young WF Jr, Eng C. Pheochromocytoma and Paraganglioma. N Engl J Med. 2019 Aug 8;381(6):552-565. doi: 10.1056/NEJMra1806651. PMID: 31390501.
- Cardiomyopathy: An OverviewBrieler J, Breeden MA, Tucker J. Cardiomyopathy: An Overview. Am Fam Physician. 2017 Nov 15;96(10):640-646. PMID: 29431384.
June 4, 2021
- Differential Diagnosis of Polyarticular ArthritisPujalte GG, Albano-Aluquin SA. Differential Diagnosis of Polyarticular Arthritis. Am Fam Physician. 2015 Jul 1;92(1):35-41. PMID: 26132125.
- An approach to joint pain and inflammatory arthropathiesGlanville JR, Higgens C, Mouyis M. An approach to joint pain and inflammatory arthropathies. Br J Hosp Med (Lond). 2016 Jul;77(7):C109-11. doi: 10.12968/hmed.2016.77.7.C109. PMID: 27388393.
- Polyarthritis and its differential diagnosisAlpay-Kanıtez N, Çelik S, Bes C. Polyarthritis and its differential diagnosis. Eur J Rheumatol. 2018 Oct 1;6(4):167-173. doi: 10.5152/eurjrheum.2019.19145. PMID: 31657698; PMCID: PMC6812894.
- SpondyloarthropathiesEhrenfeld M. Spondyloarthropathies. Best Pract Res Clin Rheumatol. 2012 Feb;26(1):135-45. doi: 10.1016/j.berh.2012.01.002. PMID: 22424199.
May 28, 2021
- Vitamin B12 Deficiency: Recognition and ManagementLangan RC, Goodbred AJ. Vitamin B12 Deficiency: Recognition and Management. Am Fam Physician. 2017 Sep 15;96(6):384-389. PMID: 28925645.
- Diagnosis and treatment of macrocytic anemias in adultsNagao T, Hirokawa M. Diagnosis and treatment of macrocytic anemias in adults. J Gen Fam Med. 2017 Apr 13;18(5):200-204. doi: 10.1002/jgf2.31. PMID: 29264027; PMCID: PMC5689413.
Note: Includes flowchart for the differential diagnosis of macrocytic anemias - Copper deficiencyMadsen E, Gitlin JD. Copper deficiency. Curr Opin Gastroenterol. 2007 Mar;23(2):187-92. doi: 10.1097/MOG.0b013e32801421bb. PMID: 17268249.
- Celiac DiseaseRubin JE, Crowe SE. In the Clinic. Celiac Disease. Ann Intern Med. 2020 Jan 7;172(1):ITC1-ITC16. doi: 10.7326/AITC202001070. PMID: 31905394; PMCID: PMC7707153.
May 26, 2021
- How I investigate eosinophiliaLarsen, R. L., & Savage, N. M. (2019). How I investigate eosinophilia. International journal of laboratory hematology, 41(2), 153-161.
- Evaluation and differential diagnosis of persistent marked eosinophiliaCurtis, C., & Ogbogu, P. U. (2015). Evaluation and differential diagnosis of persistent marked eosinophilia. Immunol Allergy Clin North Am, 35(3), 387-402.
- Diagnosis of helminth infectionsFrom: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (9th ed)
- Eosinophilic EsophagitisKatzka DA. Eosinophilic Esophagitis. Ann Intern Med. 2020 May 5;172(9):ITC65-ITC80. doi: 10.7326/AITC202005050. PMID: 32365374.
- Eosinophilic gastroenteritis: diagnosis and clinical perspectivesSunkara T, Rawla P, Yarlagadda KS, Gaduputi V. Eosinophilic gastroenteritis: diagnosis and clinical perspectives. Clin Exp Gastroenterol. 2019 Jun 5;12:239-253. doi: 10.2147/CEG.S173130. PMID: 31239747; PMCID: PMC6556468.
May 21, 2021
- Encephalopathy - causesFerri's Clinical Advisor 2021
- Infectious encephalitis: mimics and chameleonsToledano M, Davies NWS. Infectious encephalitis: mimics and chameleons. Pract Neurol. 2019 Jun;19(3):225-237. doi: 10.1136/practneurol-2018-002114. Epub 2019 Mar 16. PMID: 30878971.
- Toxic encephalopathyDobbs MR. Toxic encephalopathy. Semin Neurol. 2011 Apr;31(2):184-93. doi: 10.1055/s-0031-1277989. Epub 2011 May 17. PMID: 21590623.
- Autoimmune encephalitisGoodfellow JA, Mackay GA. Autoimmune encephalitis. J R Coll Physicians Edinb. 2019 Dec;49(4):287-294. doi: 10.4997/JRCPE.2019.407. PMID: 31808454.
- Autoimmune encephalitis: a review of diagnosis and treatmentDutra LA, Abrantes F, Toso FF, Pedroso JL, Barsottini OGP, Hoftberger R. Autoimmune encephalitis: a review of diagnosis and treatment. Arq Neuropsiquiatr. 2018 Jan;76(1):41-49. doi: 10.1590/0004-282X20170176. PMID: 29364393.
- Toxic and metabolic encephalopathiesBradley and Daroff's Neurology in Clinical Practice
- Cerebral amyloid angiopathy and related inflammatory disordersChwalisz BK. Cerebral amyloid angiopathy and related inflammatory disorders. J Neurol Sci. 2021 May 15;424:117425. doi: 10.1016/j.jns.2021.117425. Epub 2021 Mar 27. PMID: 33840507.
- Primary central nervous system vasculitisKraemer M, Berlit P. Primary central nervous system vasculitis - An update on diagnosis, differential diagnosis and treatment. J Neurol Sci. 2021 May 15;424:117422. doi: 10.1016/j.jns.2021.117422. Epub 2021 Mar 27. PMID: 33832773.
May 20, 2021
- How we manage adults with myelodysplastic syndromeFenaux P, Platzbecker U, Ades L. How we manage adults with myelodysplastic syndrome. Br J Haematol. 2020 Jun;189(6):1016-1027. doi: 10.1111/bjh.16206. Epub 2019 Sep 30. PMID: 31568568.
- Monoclonal Gammopathy of Undetermined Significance: Current Concepts and Future ProspectsSeth S, Zanwar S, Vu L, Kapoor P. Monoclonal Gammopathy of Undetermined Significance: Current Concepts and Future Prospects. Curr Hematol Malig Rep. 2020 Apr;15(2):45-55. doi: 10.1007/s11899-020-00569-2. PMID: 32222885.
- Myxedema comaKwaku MP, Burman KD. Myxedema coma. J Intensive Care Med. 2007 Jul-Aug;22(4):224-31. doi: 10.1177/0885066607301361. PMID: 17712058.
- Thyroid EmergenciesYlli D, Klubo-Gwiezdzinska J, Wartofsky L. Thyroid emergencies. Pol Arch Intern Med. 2019 Aug 29;129(7-8):526-534. doi: 10.20452/pamw.14876. Epub 2019 Jun 25. Erratum in: Pol Arch Intern Med. 2019 Sep 30;129(9):653. PMID: 31237256; PMCID: PMC6721612.
Includes Diagnostic scoring system for myxedema coma - see Table 2.
May 13, 2021
- Pathologic fractures - causesRizzo SE, Kenan S. Pathologic Fractures. 2020 Jun 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 32644503.
"The majority of neoplastic pathologic fractures are caused secondary to metastatic disease rather than primary bone tumors...There are five recognized carcinomas that most frequently metastasize to bone, including lung, breast, thyroid, renal, and prostate." - Imaging Features and Management of Stress, Atypical, and Pathologic FracturesMarshall RA, Mandell JC, Weaver MJ, Ferrone M, Sodickson A, Khurana B. Imaging Features and Management of Stress, Atypical, and Pathologic Fractures. Radiographics. 2018 Nov-Dec;38(7):2173-2192. doi: 10.1148/rg.2018180073. PMID: 30422769.
May 6, 2021
- Listeria monocytogenes: epidemiology, human disease, and mechanisms of brain invasionDrevets DA, Bronze MS. Listeria monocytogenes: epidemiology, human disease, and mechanisms of brain invasion. FEMS immunology and medical microbiology. 2008;53(2):151-165. doi:10.1111/j.1574-695X.2008.00404.x
- Otorhinolaryngological Manifestations and Its Management in COVID 19 PatientsBorah H, Das S, Goswami A. Otorhinolaryngological Manifestations and Its Management in COVID 19 Patients. Indian J Otolaryngol Head Neck Surg. 2021 Feb 17:1-4. doi: 10.1007/s12070-021-02436-9. Epub ahead of print. PMID: 33614469; PMCID: PMC7887710.
- Cutaneous sarcoidosisNoe MH, Rosenbach M. Cutaneous sarcoidosis. Curr Opin Pulm Med. 2017 Sep;23(5):482-486. doi: 10.1097/MCP.0000000000000402. PMID: 28598873.
- LymphadenopathyGaddey HL, Riegel AM. Unexplained Lymphadenopathy: Evaluation and Differential Diagnosis. Am Fam Physician. 2016 Dec 1;94(11):896-903. PMID: 27929264.
- Kikuchi-Fujimoto DiseasePerry AM, Choi SM. Kikuchi-Fujimoto Disease: A Review. Arch Pathol Lab Med. 2018 Nov;142(11):1341-1346. doi: 10.5858/arpa.2018-0219-RA. PMID: 30407860.
April 30, 2021
- Infections of the esophagusHoversten P, Kamboj AK, Katzka DA. Infections of the esophagus: an update on risk factors, diagnosis, and management. Dis Esophagus. 2018 Dec 1;31(12). doi: 10.1093/dote/doy094. PMID: 30295751.
- HIV-Associated Cancers and Related DiseasesYarchoan R, Uldrick TS. HIV-Associated Cancers and Related Diseases. N Engl J Med. 2018 Mar 15;378(11):1029-1041. doi: 10.1056/NEJMra1615896. PMID: 29539283; PMCID: PMC6890231.
- Diffuse Large B-Cell LymphomaSehn LH, Salles G. Diffuse Large B-Cell Lymphoma. N Engl J Med. 2021 Mar 4;384(9):842-858. doi: 10.1056/NEJMra2027612. PMID: 33657296.
- HIV EnteropathyMacArthur RD, DuPont HL. Etiology and pharmacologic management of noninfectious diarrhea in HIV-infected individuals in the highly active antiretroviral therapy era. Clin Infect Dis. 2012 Sep;55(6):860-7. doi: 10.1093/cid/cis544. Epub 2012 Jun 14. PMID: 22700829.
- Human intestinal spirochetosisTsinganou E, Gebbers JO. Human intestinal spirochetosis--a review. Ger Med Sci. 2010 Jan 7;8:Doc01. doi: 10.3205/000090. PMID: 20200654; PMCID: PMC2830567.
- Anal cancer and intraepithelial neoplasia screeningLeeds IL, Fang SH. Anal cancer and intraepithelial neoplasia screening: A review. World J Gastrointest Surg. 2016 Jan 27;8(1):41-51. doi: 10.4240/wjgs.v8.i1.41. PMID: 26843912; PMCID: PMC4724586.
April 29, 2021
- Altered mental status in HIV-infected patientsHo EL, Jay CA. Altered mental status in HIV-infected patients. Emerg Med Clin North Am. 2010 May;28(2):311-23, Table of Contents. doi: 10.1016/j.emc.2010.01.012. PMID: 20413014.
- Evidence-Based Approach to PalpitationsWeinstock C, Wagner H, Snuckel M, Katz M. Evidence-Based Approach to Palpitations. Med Clin North Am. 2021 Jan;105(1):93-106. doi: 10.1016/j.mcna.2020.09.004. PMID: 33246525.
- PheochromocytomaNeumann HPH, Young WF Jr, Eng C. Pheochromocytoma and Paraganglioma. N Engl J Med. 2019 Aug 8;381(6):552-565. doi: 10.1056/NEJMra1806651. PMID: 31390501.
- Adrenal IncidentalomaKebebew E. Adrenal Incidentaloma. N Engl J Med. 2021 Apr 22;384(16):1542-1551. doi: 10.1056/NEJMcp2031112. PMID: 33882207.
- American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical ApproachKiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T. ne AC, Else T. American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach. Endocr Pract. 2020 Nov;26(11):1366-1383. doi: 10.4158/DSCR-2020-0567. Epub 2020 Dec 14. PMID: 33875173; PMCID: PMC8058447.v
April 23, 2021
- Diagnosis and Management of Transient Ischemic Attack and Acute Ischemic StrokeMendelson SJ, Prabhakaran S. Diagnosis and Management of Transient Ischemic Attack and Acute Ischemic Stroke: A Review. JAMA. 2021 Mar 16;325(11):1088-1098. doi: 10.1001/jama.2020.26867. PMID: 33724327.
- Acute Ischemic StrokePowers WJ. Acute Ischemic Stroke. N Engl J Med. 2020 Jul 16;383(3):252-260. doi: 10.1056/NEJMcp1917030. PMID: 32668115.
- Adult primary central nervous system vasculitisSalvarani C, Brown RD Jr, Hunder GG. Adult primary central nervous system vasculitis. Lancet. 2012 Aug 25;380(9843):767-77. doi: 10.1016/S0140-6736(12)60069-5. Epub 2012 May 9. PMID: 22575778.
- Hemophagocytic lymphohistiocytosisGriffin G, Shenoi S, Hughes GC. Hemophagocytic lymphohistiocytosis: An update on pathogenesis, diagnosis, and therapy. Best Pract Res Clin Rheumatol. 2020 Aug;34(4):101515. doi: 10.1016/j.berh.2020.101515. Epub 2020 May 7. PMID: 32387063.
- Intravascular large B-cell lymphomaPonzoni M, Campo E, Nakamura S. Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks. Blood. 2018 Oct 11;132(15):1561-1567. doi: 10.1182/blood-2017-04-737445. Epub 2018 Aug 15. PMID: 30111607.
- American Stroke Association: Cryptogenic StrokeAmerican Stroke Association (2019). UNDERSTANDING DIAGNOSIS AND TREATMENT OF CRYPTOGENIC STROKE. Retrieved from: https://www.stroke.org
April 22, 2021
- Epidemiology and Diagnosis of MucormycosisSkiada A, Pavleas I, Drogari-Apiranthitou M. Epidemiology and Diagnosis of Mucormycosis: An Update. J Fungi (Basel). 2020 Nov 2;6(4):265. doi: 10.3390/jof6040265. PMID: 33147877; PMCID: PMC7711598.
- Orbital cellulitisTsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S. Orbital cellulitis. Surv Ophthalmol. 2018 Jul-Aug;63(4):534-553. doi: 10.1016/j.survophthal.2017.12.001. Epub 2017 Dec 15. PMID: 29248536.
- CLINICAL PRACTICE. Acute Sinusitis in AdultsRosenfeld RM. CLINICAL PRACTICE. Acute Sinusitis in Adults. N Engl J Med. 2016 Sep 8;375(10):962-70. doi: 10.1056/NEJMcp1601749. PMID: 27602668.
- In The Clinic: HyponatremiaHenry DA. In The Clinic: Hyponatremia. Ann Intern Med. 2015 Aug 4;163(3):ITC1-19. doi: 10.7326/AITC201508040. PMID: 26237763.
- Diagnosis and management of sodium disorders: hyponatremia and hypernatremiaUsed in presentation: Figure 1. Algorithm for the evaluation of hyponatremia
Braun MM, Barstow CH, Pyzocha NJ. Diagnosis and management of sodium disorders: hyponatremia and hypernatremia. Am Fam Physician. 2015 Mar 1;91(5):299-307. PMID: 25822386. - SIADHMentrasti G, Scortichini L, Torniai M, Giampieri R, Morgese F, Rinaldi S, Berardi R. Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management. Ther Clin Risk Manag. 2020 Jul 24;16:663-672. doi: 10.2147/TCRM.S206066. PMID: 32801723; PMCID: PMC7386802.
April 7, 2021
- Nausea and vomiting in adults--a diagnostic approachMetz A, Hebbard G. Nausea and vomiting in adults--a diagnostic approach. Aust Fam Physician. 2007 Sep;36(9):688-92. PMID: 17885699.
- Evaluation of nausea and vomiting: a case-based approachAnderson WD 3rd, Strayer SM. Evaluation of nausea and vomiting: a case-based approach. Am Fam Physician. 2013 Sep 15;88(6):371-9. Erratum in: Am Fam Physician. 2013 Dec 1;88(11):728. Erratum in: Am Fam Physician. 2014 Feb 1;89(3):152. PMID: 24134044.
- Hemosuccus pancreaticus: A mini-reviewYu P, Gong J. Hemosuccus pancreaticus: A mini-review. Ann Med Surg (Lond). 2018 Mar 9;28:45-48. doi: 10.1016/j.amsu.2018.03.002. PMID: 29744052; PMCID: PMC5938526.
- Zollinger-Ellison syndrome: classical considerations and current controversiesEpelboym I, Mazeh H. Zollinger-Ellison syndrome: classical considerations and current controversies. Oncologist. 2014 Jan;19(1):44-50. doi: 10.1634/theoncologist.2013-0369. Epub 2013 Dec 6. PMID: 24319020; PMCID: PMC3903066.
- Clinical aspects of multiple endocrine neoplasia type 1Al-Salameh A, Cadiot G, Calender A, Goudet P, Chanson P. Clinical aspects of multiple endocrine neoplasia type 1. Nat Rev Endocrinol. 2021 Apr;17(4):207-224. doi: 10.1038/s41574-021-00468-3. Epub 2021 Feb 9. PMID: 33564173.
March 25, 2021
- Differential Diagnosis of Polyarticular ArthritisPujalte GG, Albano-Aluquin SA. Differential Diagnosis of Polyarticular Arthritis. Am Fam Physician. 2015 Jul 1;92(1):35-41. PMID: 26132125.
- Different strategies for pharmacological thromboprophylaxis for lower-limb immobilisation after injury: systematic review and economic evaluationPandor A, Horner D, Davis S, et al. Different strategies for pharmacological thromboprophylaxis for lower-limb immobilisation after injury: systematic review and economic evaluation. Health Technol Assess. 2019;23(63):1-190. doi:10.3310/hta23630
March 19, 2021
- Clinico-haematological profile of patients with bicytopeniaSingh A, Hungund B, Kumar L, Pattanshetti M. Clinico-haematological profile of patients with bicytopenia. Pathology. 2018 Aug;50(5):540-548. doi: 10.1016/j.pathol.2018.03.008. Epub 2018 Jul 4. PMID: 30032928.
- Neutropenic FeverWhite L, Ybarra M. Neutropenic Fever. Hematol Oncol Clin North Am. 2017 Dec;31(6):981-993. doi: 10.1016/j.hoc.2017.08.004. PMID: 29078933.
- Solid Tumors of the Mediastinum in AdultsAzizad S, Sannananja B, Restrepo CS. Solid Tumors of the Mediastinum in Adults. Semin Ultrasound CT MR. 2016 Jun;37(3):196-211. doi: 10.1053/j.sult.2016.03.002. Epub 2016 Mar 9. PMID: 27261345.
- Dengue infectionGuzman MG, Gubler DJ, Izquierdo A, Martinez E, Halstead SB. Dengue infection. Nat Rev Dis Primers. 2016 Aug 18;2:16055. doi: 10.1038/nrdp.2016.55. PMID: 27534439.
March 12, 2021
- Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertensionSowers JR, Whaley-Connell A, Epstein M. Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Intern Med. 2009;150(11):776-783. doi:10.7326/0003-4819-150-11-200906020-00005
- Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trialWilliams B, MacDonald TM, Morant S, et al. Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet. 2015;386(10008):2059-2068. doi:10.1016/S0140-6736(15)00257-3
March 10, 2021
- Coagulation cascadeJohari V, Loke C. Brief overview of the coagulation cascade. Dis Mon. 2012 Aug;58(8):421-3. doi: 10.1016/j.disamonth.2012.04.004. Review. PubMed PMID: 22818555.
- An algorithmic approach to coagulation testingKlein K, Hartman SK, Teruya J, Hui SK. An algorithmic approach to coagulation testing. Dis Mon. 2012 Aug;58(8):431-9. doi: 10.1016/j.disamonth.2012.04.006. PMID: 22818557.
- Coagulation Testing in the Core LaboratoryWinter WE, Flax SD, Harris NS. Coagulation Testing in the Core Laboratory. Lab Med. 2017 Nov 8;48(4):295-313. doi: 10.1093/labmed/lmx050. PMID: 29126301.
- Von Willebrand's DiseaseLeebeek FW, Eikenboom JC. Von Willebrand's Disease. N Engl J Med. 2016 Nov 24;375(21):2067-2080. doi: 10.1056/NEJMra1601561. PMID: 27959741.
March 5, 2021
- Necrotizing Soft-Tissue InfectionsStevens DL, Bryant AE. Necrotizing Soft-Tissue Infections. N Engl J Med. 2017 Dec 7;377(23):2253-2265. doi: 10.1056/NEJMra1600673. PMID: 29211672.
- A contemporary update on Fournier's gangreneHagedorn JC, Wessells H. A contemporary update on Fournier's gangrene. Nat Rev Urol. 2017 Apr;14(4):205-214. doi: 10.1038/nrurol.2016.243. Epub 2016 Dec 13. PMID: 27958393.
March 3, 2021
- Review of Biguanide (Metformin) ToxicityWang GS, Hoyte C. Review of Biguanide (Metformin) Toxicity. J Intensive Care Med. 2019 Nov-Dec;34(11-12):863-876. doi: 10.1177/0885066618793385. Epub 2018 Aug 21. PMID: 30126348.
- Metformin-associated lactic acidosis (MALA): Moving towards a new paradigmLalau JD, Kajbaf F, Protti A, Christensen MM, De Broe ME, Wiernsperger N. Metformin-associated lactic acidosis (MALA): Moving towards a new paradigm. Diabetes Obes Metab. 2017 Nov;19(11):1502-1512. doi: 10.1111/dom.12974. Epub 2017 Jul 11. PMID: 28417525.
- Mortality rate in so-called “metformin-associated lactic acidosis”: a review of the data since the 1960sKajbaf F, Lalau JD. Mortality rate in so-called “metformin-associated
lactic acidosis”: a review of the data since the 1960s. Pharmacoepidemiol Drug Saf. 2014;23:1123-1127. - Euglycemic KetoacidosisBonora BM, Avogaro A, Fadini GP. Euglycemic Ketoacidosis. Curr Diab Rep. 2020 May 19;20(7):25. doi: 10.1007/s11892-020-01307-x. PMID: 32424730.
- Glucagon-like peptide-1 receptor agonists and risk of acute pancreatitis in patients with type 2 diabetesStorgaard H, Cold F, Gluud LL, Vilsbøll T, Knop FK. Glucagon-like peptide-1 receptor agonists and risk of acute pancreatitis in patients with type 2 diabetes. Diabetes Obes Metab. 2017 Jun;19(6):906-908. doi: 10.1111/dom.12885. Epub 2017 Mar 17. PMID: 28105738.
- Inpatient OHA ManagementPasquel FJ, Lansang MC, Dhatariya K, Umpierrez GE. Management of diabetes and hyperglycaemia in the hospital. Lancet Diabetes Endocrinol. 2021 Mar;9(3):174-188. doi: 10.1016/S2213-8587(20)30381-8. Epub 2021 Jan 27. PMID: 33515493.
- Debate on Insulin vs Non-insulin Use in the Hospital Setting-Is It Time to Revise the Guidelines for the Management of Inpatient Diabetes?Pasquel FJ, Fayfman M, Umpierrez GE. Debate on Insulin vs Non-insulin Use in the Hospital Setting-Is It Time to Revise the Guidelines for the Management of Inpatient Diabetes? Curr Diab Rep. 2019 Jul 29;19(9):65. doi: 10.1007/s11892-019-1184-8. PMID: 31353426.
- Insight Into the Perioperative Management of Type 2 DiabetesZaidi SO, Khan Y, Razak BS, Malik BH. Insight Into the Perioperative Management of Type 2 Diabetes. Cureus. 2020 Feb 4;12(2):e6878. doi: 10.7759/cureus.6878. PMID: 32190441; PMCID: PMC7058399.
February 25, 2021
- Erythrodermic psoriasisRosenbach M, Hsu S, Korman NJ, et al. Treatment of erythrodermic psoriasis: from the medical board of the National Psoriasis Foundation. J Am Acad Dermatol. 2010;62(4):655-662. doi:10.1016/j.jaad.2009.05.048
- ErythrodermaCuellar-Barboza A, Ocampo-Candiani J, Herz-Ruelas ME. A Practical Approach to the Diagnosis and Treatment of Adult Erythroderma. Eritrodermia en el adulto: un enfoque práctico para el diagnóstico y tratamiento. Actas Dermosifiliogr. 2018;109(9):777-790. doi:10.1016/j.ad.2018.05.011
February 18, 2021
- Hypersensitivity pneumonitis (includes diagnostic images)Costabel U, Miyazaki Y, Pardo A, Koschel D, Bonella F, Spagnolo P, Guzman J, Ryerson CJ, Selman M. Hypersensitivity pneumonitis. Nat Rev Dis Primers. 2020 Aug 6;6(1):65. doi: 10.1038/s41572-020-0191-z. PMID: 32764620.
- Why factor XI deficiency is a clinical concernWheeler AP, Gailani D. Why factor XI deficiency is a clinical concern. Expert Rev Hematol. 2016 Jul;9(7):629-37. doi: 10.1080/17474086.2016.1191944. Epub 2016 Jun 24. PMID: 27216469; PMCID: PMC4950943.
- Congenital factor XI deficiency: an updateDuga S, Salomon O. Congenital factor XI deficiency: an update. Semin Thromb Hemost. 2013 Sep;39(6):621-31. doi: 10.1055/s-0033-1353420. Epub 2013 Aug 8. PMID: 23929304.
February 11, 2021
- Hemolytic AnemiaPhillips J, Henderson AC. Hemolytic Anemia: Evaluation and Differential Diagnosis. Am Fam Physician. 2018 Sep 15;98(6):354-361. PMID: 30215915.
- Renal artery stenosisColbert GB, Abra G, Lerma EV. Update and review of renal artery stenosis. Dis Mon. 2020 Dec 7:101118. doi: 10.1016/j.disamonth.2020.101118. Epub ahead of print. PMID: 33303204.
February 4, 2020
- Accidental hypothermiaBrown DJ, Brugger H, Boyd J, Paal P. Accidental hypothermia. N Engl J Med. 2012 Nov 15;367(20):1930-8. doi: 10.1056/NEJMra1114208. Erratum in: N Engl J Med. 2013 Jan 24;368(4):394. PMID: 23150960.
Hypothermia Hotlines
If you see someone out in the cold:
- DC: 800-535-7252
- Arlington: 703-228-7395
February 1, 2020
- Journal Club: Controlled Trial of Budesonide-Formoterol as Needed for Mild AsthmaBeasley R, Holliday M, Reddel HK, BraithwaiBeasley R, Holliday M, Reddel HK, Braithwaite I, Ebmeier S, Hancox RJ, Harrison T, Houghton C, Oldfield K, Papi A, Pavord ID, Williams M, Weatherall M; Novel START Study Team. Controlled Trial of Budesonide-Formoterol as Needed for Mild Asthma. N Engl J Med. 2019 May 23;380(21):2020-2030. doi: 10.1056/NEJMoa1901963. Epub 2019 May 19. PMID: 31112386.. N Engl J Med. 2019 May 23;380(21):2020-2030. doi: 10.1056/NEJMoa1901963. Epub 2019 May 19. PMID: 31112386.
- Asthma - clinical reviewTripple JW, Ameredes BT, Calhoun WJ. Outpatient Management of Chronic Asthma in 2020. JAMA. 2020 Feb 11;323(6):561-562. doi: 10.1001/jama.2019.19986. PMID: 32044930.
- Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention ProgramCloutier MM, Dixon AE, Krishnan JA, Lemanske RF Jr, Pace W, Schatz M. Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program. JAMA. 2020 Dec 8;324(22):2301-2317. doi: 10.1001/jama.2020.21974. PMID: 33270095.
January 28, 2021
- Late graft failure in heart transplant recipientsLópez-Sainz Á, Barge-Caballero E, Barge-Caballero G, Couto-Mallón D, Paniagua-Martin MJ, Seoane-Quiroga L, Iglesias-Gil C, Herrera-Noreña JM, Cuenca-Castillo JJ, Vázquez-Rodríguez JM, Crespo-Leiro MG. Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes. Eur J Heart Fail. 2018 Feb;20(2):385-394. doi: 10.1002/ejhf.886. Epub 2017 Jun 5. PMID: 28580728.
- Irritable Bowel SyndromeSultan S, Malhotra A. Irritable Bowel Syndrome. Ann Intern Med. 2017 Jun 6;166(11):ITC81-ITC96. doi: 10.7326/AITC201706060. PMID: 28586906.
- Colon Ischemia: An Update for CliniciansCotter TG, Bledsoe AC, Sweetser S. Colon Ischemia: An Update for Clinicians. Mayo Clin Proc. 2016 May;91(5):671-7. doi: 10.1016/j.mayocp.2016.02.006. PMID: 27150214.
- Ischemic Colitis as a Complication of Medication Use (Alosetron)Bielefeldt K. Ischemic Colitis as a Complication of Medication Use: An Analysis of the Federal Adverse Event Reporting System. Dig Dis Sci. 2016 Sep;61(9):2655-65. doi: 10.1007/s10620-016-4162-x. Epub 2016 Apr 12. PMID: 27073073.
January 15, 2020
- Evaluation of the Solitary Pulmonary NoduleKikano GE, Fabien A, Schilz R. Evaluation of the Solitary Pulmonary Nodule. Am Fam Physician. 2015 Dec 15;92(12):1084-91. PMID: 26760594.
- Patient-Centered, Guideline-Concordant Discussion and Management of Pulmonary NodulesWiener DC, Wiener RS. Patient-Centered, Guideline-Concordant Discussion and Management of Pulmonary Nodules. Chest. 2020 Jul;158(1):416-422. doi: 10.1016/j.chest.2020.02.007. Epub 2020 Feb 17. PMID: 32081651.
- Solitary Pulmonary Nodule Malignancy Risk (Mayo Clinic model)Based on: Swensen SJ, Silverstein MD, Ilstrup DM, et al. The probability of malignancy in solitary pulmonary nodules. Application to small radiologically indeterminate nodules. Arch Intern Med. 1997 Apr 28;157(8):849-55.
- Non-Small Cell Lung CancerDuma N, Santana-Davila R, Molina JR. Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment. Mayo Clin Proc. 2019;94(8):1623–1640. doi:10.1016/j.mayocp.2019.01.013
- Small-cell lung cancerRudin CM, Brambilla E, Faivre-Finn C, Sage J. Small-cell lung cancer. Nat Rev Dis Primers. 2021 Jan 14;7(1):3. doi: 10.1038/s41572-020-00235-0. PMID: 33446664; PMCID: PMC8177722.
January 14, 2021
- Thrombotic thrombocytopenic purpuraKremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K. Thrombotic thrombocytopenic purpura. Nat Rev Dis Primers. 2017 Apr 6;3:17020. doi: 10.1038/nrdp.2017.20. PMID: 28382967.
January 13, 2021
- A Clinical Approach to Diagnosing EncephalopathyErkkinen MG, Berkowitz AL. A Clinical Approach to Diagnosing Encephalopathy. Am J Med. 2019 Oct;132(10):1142-1147. doi: 10.1016/j.amjmed.2019.07.001. Epub 2019 Jul 19. PMID: 31330129.
- Diagnosis and management of acute encephalitis: A practical approachVenkatesan A, Geocadin RG. Diagnosis and management of acute encephalitis: A practical approach. Neurol Clin Pract. 2014 Jun;4(3):206-215. doi: 10.1212/CPJ.0000000000000036. PMID: 25110619; PMCID: PMC4121461.
See Table 1: Diagnostic Criteria for Encephalitis - Autoimmune encephalitisGraus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, Cortese I, Dale RC, Gelfand JM, Geschwind M, Glaser CA, Honnorat J, Höftberger R, Iizuka T, Irani SR, Lancaster E, Leypoldt F, Prüss H, Rae-Grant A, Reindl M, Rosenfeld MR, Rostásy K, Saiz A, Venkatesan A, Vincent A, Wandinger KP, Waters P, Dalmau J. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. 2016 Apr;15(4):391-404. doi: 10.1016/S1474-4422(15)00401-9. Epub 2016 Feb 20. PMID: 26906964; PMCID: PMC5066574.
- Autoimmune encephalitis (includes typical presentations)Goodfellow JA, Mackay GA. Autoimmune encephalitis. J R Coll Physicians Edinb. 2019 Dec;49(4):287-294. doi: 10.4997/JRCPE.2019.407. PMID: 31808454.
- CNS Vasculitis: an Approach to Differential Diagnosis and ManagementByram K, Hajj-Ali RA, Calabrese L. CNS Vasculitis: an Approach to Differential Diagnosis and Management. Curr Rheumatol Rep. 2018 May 30;20(7):37. doi: 10.1007/s11926-018-0747-z. PMID: 29846828.
- Creutzfeldt-Jakob disease: recent developmentsMackenzie G, Will R. Creutzfeldt-Jakob disease: recent developments. F1000Res. 2017 Nov 27;6:2053. doi: 10.12688/f1000research.12681.1. PMID: 29225787; PMCID: PMC5710312.
- In the Clinic: DeliriumMattison MLP. In the Clinic: Delirium. Ann Intern Med. 2020 Oct 6;173(7):ITC49-ITC64. doi: 10.7326/AITC202010060. PMID: 33017552.
- Vascular disease in cocaine addictionBachi K, Mani V, Jeyachandran D, Fayad ZA, Goldstein RZ, Alia-Klein N. Vascular disease in cocaine addiction. Atherosclerosis. 2017 Jul;262:154-162. doi: 10.1016/j.atherosclerosis.2017.03.019. Epub 2017 Mar 14. PMID: 28363516; PMCID: PMC5757372.
- Full Recovery From Cocaine-Induced Toxic LeukoencephalopathyMader EC Jr, Ramos AB, Cruz RA, Branch LA. Full Recovery From Cocaine-Induced Toxic Leukoencephalopathy: Emphasizing the Role of Neuroinflammation and Brain Edema. J Investig Med High Impact Case Rep. 2019 Jan-Dec;7:2324709619868266. doi: 10.1177/2324709619868266. PMID: 31409155; PMCID: PMC6696843.
January 8, 2020
- Immune Reconstitution Inflammatory Syndrome (IRIS): What pathologists should knowNelson AM, Manabe YC, Lucas SB. Immune Reconstitution Inflammatory Syndrome (IRIS): What pathologists should know. Semin Diagn Pathol. 2017 Jul;34(4):340-351. doi: 10.1053/j.semdp.2017.04.010. Epub 2017 Apr 26. PMID: 28552210.
- Paradoxical Reactions and the Immune Reconstitution Inflammatory SyndromeChurch LWP, Chopra A, Judson MA. Paradoxical Reactions and the Immune Reconstitution Inflammatory Syndrome. Microbiol Spectr. 2017 Mar;5(2). doi: 10.1128/microbiolspec.TNMI7-0033-2016. PMID: 28303782.
- HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatmentBowen LN, Smith B, Reich D, Quezado M, Nath A. HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment. Nat Rev Neurol. 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149. PMID: 27786246.
- Cytomegalovirus Retinitis in HIV and Non-HIV IndividualsMunro M, Yadavalli T, Fonteh C, Arfeen S, Lobo-Chan AM. Cytomegalovirus Retinitis in HIV and Non-HIV Individuals. Microorganisms. 2019 Dec 28;8(1):55. doi: 10.3390/microorganisms8010055. PMID: 31905656; PMCID: PMC7022607.
